( ! ) Notice: La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.) in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0003360888{main}( ).../index.php:0
20.0004362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1198105061624require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1541105560248apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1542105560656WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1542105562192Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1542105562672Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1542105566016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1542105582784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1542105583160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1542105583160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1543105585616wp_enqueue_scripts( '' ).../class-wp-hook.php:341
131.1543105585616do_action( $hook_name = 'wp_enqueue_scripts' ).../script-loader.php:2311
141.1543105585992WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
151.1543105585992WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
161.1851105970208App\Setup\Hooks->enqueueAssets( '' ).../class-wp-hook.php:341
171.1852105970312wp_localize_script( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../Hooks.php:138
181.1852105970312WP_Scripts->localize( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../functions.wp-scripts.php:233
191.1853105970632_doing_it_wrong( $function_name = 'WP_Scripts::localize', $message = 'Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>.', $version = '5.7.0' ).../class-wp-scripts.php:616
201.1854105971976wp_trigger_error( $function_name = '', $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = ??? ).../functions.php:6071
211.1856105972448trigger_error( $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = 1024 ).../functions.php:6131
Monitoring non-invasif de biomarqueurs immunitaires pour l’identification précoce de l’échappement tumoral à l’immunothérapie chez des patients atteints d’un carcinome broncho-pulmonaire non à petites cellules de stade avancé ou métastatique - Fondation BMS
( ! ) Notice: file_get_contents(): Read of 8192 bytes failed with errno=21 Is a directory in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 4681
Call Stack
#TimeMemoryFunctionLocation
10.0003360888{main}( ).../index.php:0
20.0004362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1198105061624require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1541105560248apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1542105560656WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1542105562192Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1542105562672Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1542105566016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1542105582784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1542105583160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1542105583160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.2299107426752wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.2299107426752WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.2299107426752wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.2299107426808WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.2495107983512WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.2496107984152WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.2496107984152wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.2497107984640file_get_contents( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources' ).../functions.php:4681

( ! ) Notice: wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0003360888{main}( ).../index.php:0
20.0004362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1198105061624require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1541105560248apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1542105560656WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1542105562192Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1542105562672Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1542105566016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1542105582784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1542105583160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1542105583160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.2299107426752wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.2299107426752WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.2299107426752wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.2299107426808WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.2495107983512WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.2496107984152WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.2496107984152wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.2508108009896wp_trigger_error( $function_name = 'wp_json_file_decode', $message = 'Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = ??? ).../functions.php:4690
201.2509108010216trigger_error( $message = 'wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = 1024 ).../functions.php:6131

Monitoring non-invasif de biomarqueurs immunitaires pour l’identification précoce de l’échappement tumoral à l’immunothérapie chez des patients atteints d’un carcinome broncho-pulmonaire non à petites cellules de stade avancé ou métastatique

Malgré les effets cliniques durables obtenus avec les inhibiteurs des points de contrôle immunitaires PD-1/PD-L1, la majorité des patients atteints d’un cancer broncho-pulmonaire non à petites cellules (CBPNPC) de stade avancé ou métastatique sont réfractaires ou développent une résistance acquise après une réponse initiale. Ces réponses différentes aux immunothérapies reposent sur une interaction dynamique entre les facteurs tumoraux et immunitaires qui est variable selon ces patients. L’objectif principal de ce projet est d’évaluer le caractère prédictif de réponse et le profil de toxicité à l’aide d’une signature complexe combinant l’immunoréactivité des lymphocytes T cytotoxiques sanguins et le répertoire de leurs récepteurs TCR, avant et pendant le traitement avec des inhibiteurs de PD-1/PD-L1 chez des patients atteints d’un CBPNPC de stade avancé ou métastatique.

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