( ! ) Notice: La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.) in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0001359864{main}( ).../index.php:0
20.0002361264require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0492105093928require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0757105606832apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0757105607240WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0757105608776Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0757105609256Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0757105612600Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0757105629368do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0758105629744WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0758105629744WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.0758105632200wp_enqueue_scripts( '' ).../class-wp-hook.php:341
131.0758105632200do_action( $hook_name = 'wp_enqueue_scripts' ).../script-loader.php:2311
141.0758105632576WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
151.0758105632576WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
161.1050106003136App\Setup\Hooks->enqueueAssets( '' ).../class-wp-hook.php:341
171.1051106003240wp_localize_script( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../Hooks.php:138
181.1051106003240WP_Scripts->localize( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../functions.wp-scripts.php:233
191.1052106003560_doing_it_wrong( $function_name = 'WP_Scripts::localize', $message = 'Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>.', $version = '5.7.0' ).../class-wp-scripts.php:616
201.1053106004904wp_trigger_error( $function_name = '', $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = ??? ).../functions.php:6071
211.1055106005376trigger_error( $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = 1024 ).../functions.php:6131
 Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP) - Fondation BMS
( ! ) Notice: file_get_contents(): Read of 8192 bytes failed with errno=21 Is a directory in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 4681
Call Stack
#TimeMemoryFunctionLocation
10.0001359864{main}( ).../index.php:0
20.0002361264require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0492105093928require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0757105606832apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0757105607240WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0757105608776Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0757105609256Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0757105612600Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0757105629368do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0758105629744WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0758105629744WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1454107429536wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.1454107429536WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.1454107429536wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.1454107429592WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.1635107986296WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.1637107986936WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.1637107986936wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.1637107987424file_get_contents( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources' ).../functions.php:4681
( ! ) Notice: wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0001359864{main}( ).../index.php:0
20.0002361264require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0492105093928require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0757105606832apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0757105607240WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0757105608776Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0757105609256Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0757105612600Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0757105629368do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0758105629744WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0758105629744WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1454107429536wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.1454107429536WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.1454107429536wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.1454107429592WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.1635107986296WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.1637107986936WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.1637107986936wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.1647108012680wp_trigger_error( $function_name = 'wp_json_file_decode', $message = 'Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = ??? ).../functions.php:4690
201.1648108013000trigger_error( $message = 'wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = 1024 ).../functions.php:6131
Actualités Vidéothèque Contact
picto
RECHERCHE
Onco-Pédiatrie
Actualités Contact

Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)

Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l’enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.
Ce projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.
Cette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non diagnostiqué chez des enfants atteints de lymphomes, pour une application clinique. Plus largement, les résultats contribueront à améliorer la prise en charge des patients avec un lymphome, enfants ou adultes. L’hôpital pédiatrique Necker est idéalement positionné pour mener ce projet grâce à son expertise en génétique constitutionnelle et somatique sur les lymphomes, couvrant les spécialités pédiatriques et adultes.

Sujets relatifs

APPEL À PROJET 14 / 2025
Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas
David Castel
Equipe Génomique & Oncogenèse des Tumeurs Cérébrales Pédiatriques
APPEL À PROJET 13 / 2024
Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques
Fanny ALBY-LAURENT
Hôpital Armand Trousseau, APHP, Sorbonne Université
APPEL À PROJET 13 / 2024
Boolean logic-gated immunotherapy to efficiently eradicate pediatric high-grade glioma
Claire Pecqueur
CRCI2NA, Centre de Recherche en Cancérologie et Immunologie Integrée- Nantes Angers
Découvrez les autres projets