( ! ) Notice: La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.) in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0001360888{main}( ).../index.php:0
20.0002362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1588105061880require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1869105557112apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1870105557520WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1870105559056Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1870105559536Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1870105562880Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1870105579648do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1870105580024WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1870105580024WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1871105582480wp_enqueue_scripts( '' ).../class-wp-hook.php:341
131.1871105582480do_action( $hook_name = 'wp_enqueue_scripts' ).../script-loader.php:2311
141.1871105582856WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
151.1871105582856WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
161.2190105967072App\Setup\Hooks->enqueueAssets( '' ).../class-wp-hook.php:341
171.2191105967176wp_localize_script( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../Hooks.php:138
181.2191105967176WP_Scripts->localize( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../functions.wp-scripts.php:233
191.2192105967496_doing_it_wrong( $function_name = 'WP_Scripts::localize', $message = 'Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>.', $version = '5.7.0' ).../class-wp-scripts.php:616
201.2193105968840wp_trigger_error( $function_name = '', $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = ??? ).../functions.php:6071
211.2195105969312trigger_error( $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = 1024 ).../functions.php:6131
 Comprendre les conséquences des approches thérapeutiques standards sur le microenvironnement immunitaire des médulloblastomes pour favoriser une immunité antitumorale. - Fondation BMS
( ! ) Notice: file_get_contents(): Read of 8192 bytes failed with errno=21 Is a directory in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 4681
Call Stack
#TimeMemoryFunctionLocation
10.0001360888{main}( ).../index.php:0
20.0002362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1588105061880require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1869105557112apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1870105557520WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1870105559056Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1870105559536Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1870105562880Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1870105579648do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1870105580024WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1870105580024WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.2613107423232wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.2613107423232WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.2613107423232wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.2613107423288WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.2801107979992WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.2802107980632WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.2802107980632wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.2803107981120file_get_contents( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources' ).../functions.php:4681
( ! ) Notice: wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0001360888{main}( ).../index.php:0
20.0002362288require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.1588105061880require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.1869105557112apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.1870105557520WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.1870105559056Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.1870105559536Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.1870105562880Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.1870105579648do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.1870105580024WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.1870105580024WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.2613107423232wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.2613107423232WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.2613107423232wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.2613107423288WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.2801107979992WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.2802107980632WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.2802107980632wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.2813108006376wp_trigger_error( $function_name = 'wp_json_file_decode', $message = 'Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = ??? ).../functions.php:4690
201.2814108006696trigger_error( $message = 'wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = 1024 ).../functions.php:6131
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Comprendre les conséquences des approches thérapeutiques standards sur le microenvironnement immunitaire des médulloblastomes pour favoriser une immunité antitumorale.

Le médulloblastome (MB) est la tumeur cérébrale maligne la plus fréquente de l’enfant. Quatre sous-groupes majeurs de MB ont été identifiés. Ils sont traités par une stratégie incluant : chirurgie, irradiation cranio-spinale et chimiothérapie. En dépit d’une approche multimodale agressive, 30% des patients restent incurables et les survivants souffrent d’important effets secondaires. Le développement de therapies plus efficaces et moins toxiques est une priorité. Les immunothérapies ont émergé comme des approches efficaces dans le traitement du cancer, mais n’auraient qu’une efficacité limitée sur les MB. Néanmoins, notre groupe et d’autres suggèrent qu’une meilleure compréhension de la communication entre les cellules tumorales et leur environnement immunitaire (iTME) permettrait de développer des approches thérapeutiques plus efficaces. Ce projet a pour but de caractériser les conséquences des thérapies standards par irradiation et chimiothérapies sur le iTME, afin d’identifier de potentielles synergies de traitement, des biomarqueurs de résistances et ainsi proposer de nouvelles stratégies thérapeutiques pour les MB et d’autres tumeurs cérébrales primaires et métastatiques.

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