RECHERCHE
Fondamentale
EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.
Découvrez la vidéo de la cérémonie 2024 à Lyon
Découvrir les projets lauréats
RECHERCHE
Clinique & translationnelle
Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques
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Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../Hooks.php:121 |
| 8 | 1.2689 | 107934704 | Jenssegers\Blade\Blade->render( $view = 'single-video-library', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.2707 | 107992688 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.2707 | 107992688 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.2707 | 107992744 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.2707 | 107993440 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../View.php:139 |
| 13 | 1.2709 | 107994136 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.2709 | 108010648 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../PhpEngine.php:58 |
| 15 | 1.2709 | 108011408 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.2710 | 108025128 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php ) | .../Filesystem.php:107 |
| 17 | 1.2914 | 108254872 | Illuminate\View\View->render( $callback = ??? ) | .../99959100aa5db5b06d6ff30b783f4db1635206cf.php:20 |
| 18 | 1.2914 | 108254872 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.2914 | 108254872 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.2914 | 108255568 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'showAxe' => TRUE] ) | .../View.php:139 |
| 21 | 1.2915 | 108255728 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; 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protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'showAxe' => TRUE] ) | .../CompilerEngine.php:61 |
| 22 | 1.2915 | 108272240 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34951', 1 => '34961', 2 => '35014'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34951,34961,35014) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35014; public $post_author = '17591'; public $post_date = '2024-04-10 19:54:14'; public $post_date_gmt = '2024-04-10 17:54:14'; public $post_content = 'Au-delà des paramètres immuns, des études récentes montrent que des paramètres intrinsèques aux cellules tumorales régulent la réponse aux immunothérapies (IT). Dans le mélanome cutané (MC), nous avons démontré que les cellules tumorales dé-différenciées sont associées à la résistance aux IT, en favorisant un microenvironnement immunosuppressif. Cette plasticité tumorale non-génétique est régulée par des altérations transcriptionnelles suite à des modifications de la chromatine. Toutefois, les régulateurs épigénétiques impliqués et les mécanismes sous-jacents restent à caractériser afin de mieux comprendre leur mode d’action et envisager leur ciblage thérapeutique. Nous avons récemment identifié TRIM24, un régulateur épigénétique associé à la dé-différenciation des cellules de MC dont l’expression corrèle avec la résistance à l’IT chez les patients. Notre projet vise à mieux comprendre le rôle de TRIM24 dans l’échappement immunitaire et la résistance'...; public $post_title = 'EpiMel – Comprendre le rôle du régulateur épigénétique TRIM24 dans la résistance à l’immunothérapie dans le mélanome cutané et évaluer son ciblage thérapeutique.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:11:34'; public $post_modified_gmt = '2025-09-23 14:11:34'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epimel-comprendre-le-role-du-regulateur-epigenetique-trim24-dans-la-resistance-a-limmunotherapie-dans-le-melanome-cutane-et-evaluer-son-ciblage-therapeutique/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 34961; public $post_author = '17532'; public $post_date = '2024-04-10 13:29:09'; public $post_date_gmt = '2024-04-10 11:29:09'; public $post_content = 'Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L\'essai ATALANTE (NCT02891824) a évalué l\'ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n\'a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 '...; public $post_title = 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:12'; public $post_modified_gmt = '2025-09-23 14:10:12'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-du-micro-environnement-des-cancers-ovariens-de-haut-grade-validation-de-mecanismes-de-reponse-resistance-a-limmunotherapie-et-identification-de-nouvelles-cibles-ther/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 34951; public $post_author = '331'; public $post_date = '2024-04-10 11:44:04'; public $post_date_gmt = '2024-04-10 09:44:04'; public $post_content = 'Malgré la révolution que constitue le développement des immunothérapies du cancer, et notamment les thérapies dites « inhibiteurs de checkpoint » (tels que les anticorps anti-PD-1), seule une faible proportion des patients répond favorablement à ces traitements. Les lymphocytes T CD8 sont des cellules immunitaires ayant un rôle crucial dans le contrôle de la progression tumorale et la réponse aux inhibiteurs de checkpoint. La compréhension des mécanismes orchestrant l’activité de ces cellules pourrait donc mettre en évidence de nouvelles cibles d’immunothérapie.\r\nNous avons identifié une protéine intracellulaire nommée c-Rel comme indispensable à l’activité des lymphocytes T CD8 dans des modèles de mélanome. Notre projet vise désormais à déterminer si c-Rel est requis pour la réponse aux inhibiteurs de checkpoint, et à identifier les mécanismes précis permettant cette activité. D’autre part, nous souhaitons évaluer l’effet d’une modulation de c-Rel dans l’efficac'...; public $post_title = 'Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:09:38'; public $post_modified_gmt = '2025-09-23 14:09:38'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/etude-du-role-et-du-ciblage-therapeutique-dune-proteine-des-lymphocytes-t-dans-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 3; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f8b1778eea810ad8e27656fa555e48e0'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:64ea3878c48beb36b351f95c19bfad8a' }, 'prev' => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'next' => class WP_Post { public $ID = 36727; public $post_author = '1'; public $post_date = '2025-09-23 16:12:45'; public $post_date_gmt = '2025-09-23 14:12:45'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Curie'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-institut-curie'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:09:43'; public $post_modified_gmt = '2025-09-24 07:09:43'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36727'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'showAxe' => TRUE] ) | .../PhpEngine.php:58 |
| 23 | 1.2915 | 108273000 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 24 | 1.2917 | 108284296 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php ) | .../Filesystem.php:107 |
| 25 | 1.2917 | 108284296 | App\Project\Helpers::getInfos( $postID = 34951 ) | .../58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php:1 |
RECHERCHE
Fondamentale
Etude du rôle et du ciblage thérapeutique d’une protéine des lymphocytes T dans le mélanome.