RECHERCHE
Santé publique & organisation de soins
Immunothérapie du mélanome en HAD : parcours de soins dédié.
Découvrez la vidéo de la cérémonie 2024 à Toulouse
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RECHERCHE
Fondamentale
Caractérisation d’un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome
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Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. 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Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. 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| 8 | 1.3204 | 107999128 | Jenssegers\Blade\Blade->render( $view = 'single-video-library', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3221 | 108057112 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3221 | 108057112 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3221 | 108057168 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3221 | 108057864 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../View.php:139 |
| 13 | 1.3222 | 108058560 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3222 | 108075072 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3222 | 108075832 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3224 | 108089552 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/99959100aa5db5b06d6ff30b783f4db1635206cf.php ) | .../Filesystem.php:107 |
| 17 | 1.3404 | 108318040 | Illuminate\View\View->render( $callback = ??? ) | .../99959100aa5db5b06d6ff30b783f4db1635206cf.php:20 |
| 18 | 1.3404 | 108318040 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3405 | 108318040 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3405 | 108318736 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'showAxe' => TRUE] ) | .../View.php:139 |
| 21 | 1.3406 | 108318896 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 4; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '0d58042d7fbf6d18205c267e30677c8d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:b376742fbb2709f6127b8ad702c593b9' }, 'prev' => '', 'next' => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 'showAxe' => TRUE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3406 | 108335408 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-video-library.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [], 'composing: single-video-library' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-video-library' => [...], 'composing: single-video-library' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => [], 'bgHeader' => '', 'bgHeaderMobile' => '', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154']]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => -1, 'post__in' => [0 => '34834', 1 => '35004', 2 => '35083', 3 => '35154'], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = []; public $relation = NULL; public $meta_table = NULL; public $meta_id_column = NULL; public $primary_table = NULL; public $primary_id_column = NULL; protected $table_aliases = []; protected $clauses = []; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts \n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID IN (34834,35004,35083,35154) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t \n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 35154; public $post_author = '17509'; public $post_date = '2024-04-11 18:38:31'; public $post_date_gmt = '2024-04-11 16:38:31'; public $post_content = 'L’immunothérapie (IT) a révolutionné le pronostic du mélanome métastatique avec des données actualisées récentes montrant des taux de survie globale à 7.5 ans de près de 50%. La durée idéale de traitement n’est pas clairement définie et si la durée de prise en charge du mélanome évolue de façon favorable avec des perspectives de survie à long terme, cette dynamique entraîne de nouveaux besoins en santé, guidés notamment par la nécessité de mieux prendre en compte de la qualité de vie du patient. Ce changement de paradigme pousse à une modification des pratiques dont le développement des soins à domicile. L\'administration d\'une IT au domicile passe uniquement par une Hospitalisation à Domicile (HAD) du fait d’un traitement réservé à l’usage hospitalier. Les établissements d\'HAD sont soumis aux mêmes obligations que les établissements de santé et fonctionnent avec leur propre équipe médicale et paramédicale. La mise en oeuvre de ce parcours requiert des compétences'...; public $post_title = 'Immunothérapie du mélanome en HAD : parcours de soins dédié.'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:20:24'; public $post_modified_gmt = '2025-09-23 14:20:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/immunotherapie-du-melanome-en-had-parcours-de-soins-dedie-2/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 35083; public $post_author = '124'; public $post_date = '2024-04-11 13:24:18'; public $post_date_gmt = '2024-04-11 11:24:18'; public $post_content = 'Les thérapies basées sur le blocage des checkpoints immunitaires (CI) reposent principalement sur des approches combinatoires ciblant des récepteurs inhibiteurs distincts. Des effets inhibiteurs coopératifs entre les CI ont été suggérés mais les mécanismes impliqués restent mal définis. Nous proposons ici d\'étudier les mécanismes de coopération de deux checkpoints immunitaires structurellement apparentés co-exprimés sur les lymphocytes T infiltrant les tumeurs. En utilisant des modèles de souris présentant des déficiences conditionnelles individuelles ou combinées de ces checkpoints dans les lymphocytes T, nous conduirons des analyses de cytométrie à haute dimension et de transcriptomique en cellule unique pour caractériser les effets coopératifs de ces récepteurs dans l’environnement tumorale. En utilisant des modèles de mélanome conçus pour exprimer des antigènes tumoraux de différentes affinités pour le TCR, nous analyserons si ces récepteurs inhibent plus efficacement la '...; public $post_title = 'Caractérisation d\'un mécanisme de coopération de deux checkpoints immunitaires régulant la réponse des lymphocytes T contre le mélanome'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:18:53'; public $post_modified_gmt = '2025-09-23 14:18:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/caracterisation-dun-mecanisme-de-cooperation-de-deux-checkpoints-immunitaires-regulant-la-reponse-des-lymphocytes-t-contre-le-melanome/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. Nous cherchons 1) à identifier les patients pouvant répondre à l’immunothérapie et 2) à développer un traitement efficace pour les patients non répondeurs, chez qui les métastases hépatiques sont particulièrement résistantes. L’intestin, organe des tumeurs primitives, possède une immunité particulière, comprenant des cellules T localement activées. Nous venons de découvrir que les tumeurs coliques pourraient exercer un effet anti-métastases, en activant spontanément des lymphocytes T CD8 intestinaux, capables d’émigrer du colon, atteindre des métastases et les éliminer. Ce projet vise à comprendre et exploiter les propriétés antitumorales considérables des lymphocytes T CD8 intestinaux dans le mCRC. Nous étudierons en détail les caractéristiques, les capacités migratoires et cytotoxiques de ces '...; public $post_title = 'Ciblage de l\'immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:10:53'; public $post_modified_gmt = '2025-09-23 14:10:53'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/ciblage-de-limmunite-intestinale-pour-lutter-contre-les-metastases-dans-le-cancer-colorectal-targeting-intestinal-immunity-to-develop-effective-therapies-against-metastases/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 3 => class WP_Post { public $ID = 34834; public $post_author = '17562'; public $post_date = '2024-04-05 18:03:28'; public $post_date_gmt = '2024-04-05 16:03:28'; public $post_content = 'Cette étude analysera l’impact de la défavorisation sociale, d’une part sur l’administration de l’immunothérapie, et d’autre part sur la survie des Cancers du poumon non à petites cellules (CPNPC) traités par immunothérapie. Le projet, sur 24 mois, sera coordonné par le réseau français des registres de cancer FRANCIM et l’Oncopole Claudius Regaud, en collaboration avec le CERPOP (UMR1295 Inserm). Deux sources de données seront mobilisées et appariées. D’une part, un échantillon représentatif des données des registres de cancers des cas diagnostiqués en 2019, 2020 et 2021 (~ 4600 cas) documentera la prise en charge et les caractéristiques cliniques des tumeurs, dont la recherche d’expression et le % d’expression de PDL1 par les tumeurs, ainsi que l’environnement socioéconomique des individus. D’autre part, les données exhaustives de l’assurance maladie obligatoire française (SNDS) permettra de décrire le traitement par immunothérapie, les comorbidités, la survie Ã'...; public $post_title = 'Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 15:42:11'; public $post_modified_gmt = '2025-09-23 13:42:11'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cancer-du-poumon-non-a-petites-cellules-etude-des-facteurs-sociodemographiques-dacces-et-defficacite-de-limmunotherapie-en-population-generale/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 4; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 35004; public $post_author = '433'; public $post_date = '2024-04-10 18:35:40'; public $post_date_gmt = '2024-04-10 16:35:40'; public $post_content = 'Dans le cancer colorectal métastatique (mCRC), les immunothérapies, boostant la réponse antitumorale, sont efficaces chez certains patients cependant, beaucoup restent incurables. 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RECHERCHE
Fondamentale
Ciblage de l’immunité intestinale pour lutter contre les métastases dans le cancer colorectal/ Targeting intestinal immunity to develop effective therapies against metastases
RECHERCHE
Santé publique & organisation de soins
Cancer du poumon non à petites cellules : Etude des facteurs sociodémographiques d’accès et d’efficacité de l’immunothérapie en population générale