Découvrez l’interview de Sophie LAFFONT-PRADINES
Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer
Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la dissémination métastatique et la réponse aux inhibiteurs de points de contrôle immunitaire dans des modèles de mélanome. Notre projet mettra en lumière des mécanismes moléculaires différenciés selon le sexe, exploitables en immunothérapie. Il fournira aussi des informations clés sur la manière dont les épidrugs – drogues épigénétiques – ciblant par exemple EZH2, tels que le Tazemetostat, pourraient influencer les réponses anti-tumorales en perturbant la marque répressive H3K27me3 enrichie sur le chromosome X inactif.
Vidéo du projet
Sujets relatifs
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Elargir l’arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine
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public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }] ) | .../Hooks.php:121 |
| 8 | 1.3002 | 108006824 | Jenssegers\Blade\Blade->render( $view = 'single-project', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3018 | 108064808 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3018 | 108064808 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3019 | 108064864 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3019 | 108065560 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }] ) | .../View.php:139 |
| 13 | 1.3020 | 108066256 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3020 | 108082768 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3020 | 108083528 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3021 | 108103448 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php ) | .../Filesystem.php:107 |
| 17 | 1.3278 | 108409008 | Illuminate\View\View->render( $callback = ??? ) | .../403aef9b1827d569d3508f34a847de4a633c2323.php:40 |
| 18 | 1.3278 | 108409008 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3278 | 108409008 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3278 | 108410344 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }, 'showAxe' => FALSE] ) | .../View.php:139 |
| 21 | 1.3279 | 108410504 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '56d187bed0eb62bbf4bf7f5d58794ff6'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }, 'showAxe' => FALSE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3279 | 108427016 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [36330 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/apafis.pdf', 36331 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettredu.pdf', 36332 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/lettrechefdequipe.pdf', 36333 => 'https://fondation-bms.ontest.net/wp-content/uploads/2025/04/dysix.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 36329], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (36329) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 2; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36111; public $post_author = '17484'; public $post_date = '2025-04-10 18:21:03'; public $post_date_gmt = '2025-04-10 16:21:03'; public $post_content = 'L\'ADN libéré lors de la mort des cellules tumorales joue un rôle crucial dans les réponses antitumorales. Après détection par la voie cGAS/STING, cet ADN peut soit stimuler l\'immunité antitumorale en activant la sécrétion d\'IFN de type I par les cellules dendritiques, soit favoriser la tolérance tumorale en recrutant des cellules immunosuppressives. Des études récentes ont montré que cette stimulation des voies de détection de l’ADN peut optimiser l’efficacité des thérapies par les inhibiteurs de points de contrôle immunitaire, comme les anticorps anti-PD1. Malgré son rôle crucial, les mécanismes régulant le potentiel immunomodulateur de l’ADN tumoral restent peu compris. Nous avons identifié une enzyme, la DNASE1L3, qui digère l’ADN endogène, limitant ainsi le risque d\'auto-immunité. Son rôle dans les cancers reste peu exploré. Dans un modèle de cancer mammaire syngénique orthotopique, nous avons observé que l\'absence de cette enzyme compromet l\'efficacité thérapeutiqu'...; public $post_title = 'La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:10:32'; public $post_modified_gmt = '2025-06-30 16:10:32'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/la-dnase1l3-un-acteur-important-dans-la-regulation-des-reponses-antitumorales-et-un-facteur-cle-de-lefficacite-therapeutique-des-immunotherapies/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f05f91dd8520689c2fef4d2f0a9ef417'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:f1b9a9563eb6b70d9483220ac7151045' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 36329]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 36329], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 36329, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'36329\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; 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public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36765; public $post_author = '1'; public $post_date = '2025-10-16 13:57:42'; public $post_date_gmt = '2025-10-16 11:57:42'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Sophie LAFFONT-PRADINES'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-sophie-laffont-pradines'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-10-16 14:13:09'; public $post_modified_gmt = '2025-10-16 12:13:09'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36765'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; 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private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:a5c3e74a1115191ce18744c4a2a6bbe7' }, 'showAxe' => FALSE] ) | .../PhpEngine.php:58 |
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La DNASE1L3 : un acteur important dans la régulation des réponses antitumorales et un facteur-clé de l’efficacité thérapeutique des immunothérapies ?