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Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques
Malgré une prise en charge optimale, la majorité des patientes avec un cancer ovarien (CO) rechutent et le suivi devient palliatif. Bien que les cellules immunes infiltrent les CO de haut grade, l’immunothérapie (IT) est peu efficace. L’essai ATALANTE (NCT02891824) a évalué l’ajout d’un anticorps (Ac) anti-PD-L1 à la chimiothérapie à base de sels de platine (CT) et au bevacizumab chez les patientes en rechute d’un CO. La survie sans progression n’a pas été améliorée mais les données de survie globale suggèrent que certaines patientes bénéficieraient de l’IT (anti-PD-L1: médiane à 35,5 mois; placebo: 30,6 mois; HR:0,81; IC95% 0.65-1.01). Selon nos résultats antérieurs, nous supposons que le score «HOT» (PD-L1, lymphocytes T (LT) CD8pos, voie IFN-γ active), est un marqueur de réponse à l’IT contrairement à PD-L1 seul qui ne prédit pas la réponse dans ATALANTE. A l’inverse, nous avons montré dans l’essai NeoPembrOv (NCT03275506), évaluant l’ajout d’un Ac anti-PD-1 à la CT, que VEGFR2 (facteur angiogénique), les macrophages TREM2pos et les LT régulateurs seraient des marqueurs de résistance à l’IT. Nous proposons de valider l’impact prédictif de ces marqueurs dans la cohorte ATALANTE par séquençage ARN et immunofluorescence multiplex et d’explorer les interactions cellulaires par transcriptomique spatiale. Ce projet permettra une caractérisation profonde des CO et aidera à définir de nouveaux biomarqueurs de réponse/résistance à l’IT et de nouvelles combinaisons thérapeutiques.
Vidéo du projet
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public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }] ) | .../Hooks.php:121 |
| 8 | 1.3222 | 107983184 | Jenssegers\Blade\Blade->render( $view = 'single-project', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3248 | 108041168 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3248 | 108041168 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3248 | 108041224 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3248 | 108041920 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }] ) | .../View.php:139 |
| 13 | 1.3250 | 108042616 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3250 | 108059128 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3250 | 108059888 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3252 | 108079808 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php ) | .../Filesystem.php:107 |
| 17 | 1.3300 | 108225472 | Illuminate\View\View->render( $callback = ??? ) | .../403aef9b1827d569d3508f34a847de4a633c2323.php:31 |
| 18 | 1.3300 | 108225472 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3300 | 108225536 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3300 | 108226872 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }, 'titlePost' => TRUE] ) | .../View.php:139 |
| 21 | 1.3302 | 108227032 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }, 'titlePost' => TRUE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3302 | 108243544 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Caractérisation du micro-environnement des cancers ovariens de haut grade – validation de mécanismes de réponse/résistance à l’immunothérapie et identification de nouvelles cibles thérapeutiques'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34963 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_annexes.pdf', 34964 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/clb_statuts_jo.pdf', 34965 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/autorisation-soutien-jyb-atalanteimmmune-bms2024-o-le-saux.pdf', 34966 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/2024-04-10-lettre-dengagement-de-disponibilite-des-echantillons-biologiques-atalante.pdf', 34962 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/atalanteimmune_ols_bms2024_description-projet-recherche.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34961], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '11'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '11', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34961) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'11\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36136; public $post_author = '17666'; public $post_date = '2025-04-10 23:34:02'; public $post_date_gmt = '2025-04-10 21:34:02'; public $post_content = 'Les cancers bronchiques à petites cellules (CPC) représentent un sous-groupe de cancers pulmonaires de mauvais pronostic. Au stade étendu, le traitement repose sur la chimiothérapie associée à une immunothérapie par anti-PD-L1. L’étude du profil transcriptionnel d’échantillons tumoraux de CPC a permis de définir quatre sous-types moléculaires aux vulnérabilités thérapeutiques particulières. La stabilité de ces sous-types au cours des traitements anti-cancéreux est encore mal connue en raison de l’absence d’échantillons tumoraux prélevés après le diagnostic initial. Le projet EPICIRC SCLC a pour objectif d’étudier, chez des patients atteints de CPC étendu, l’évolution des 4 sous-types moléculaires durant la première ligne de chimio-immunothérapie, grâce à un profilage épigénomique de l\'ADN circulant libre sur des échantillons de plasma prélevés au diagnostic, après 3 mois de traitement, et à la progression tumorale. Des analyses épigénomiques, incluant la méth'...; public $post_title = 'Epigenomic Profiling of Circulating Free DNA (cfDNA) to Characterize the Dynamic Evolution of Extensive Stage Small Cell Lung Cancer Molecular Subtypes During First-Line Chemo-Immunotherapy (EPICIRC SCLC).'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:06:24'; public $post_modified_gmt = '2025-06-30 16:06:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/epigenomic-profiling-of-circulating-free-dna-cfdna-to-characterize-the-dynamic-evolution-of-extensive-stage-small-cell-lung-cancer-molecular-subtypes-during-first-line-chemo-immunotherapy-epicirc-s/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36092; public $post_author = '17699'; public $post_date = '2025-04-10 17:33:49'; public $post_date_gmt = '2025-04-10 15:33:49'; public $post_content = 'Les tumeurs rhabdoïdes (TR) sont des tumeurs agressives de la petite enfance, caractérisées par la perte de SMARCB1, un composant clé du complexe de remodelage de la chromatine SWI/SNF, sans autres mutations récurrentes et avec une charge mutationnelle remarquablement faible. Actuellement, le traitement repose sur une combinaison de chirurgie, chimiothérapie et radiothérapie, mais ces approches restent inefficaces pour de nombreux patients et entraînent des séquelles graves. Nos travaux récents ont montré que, contrairement aux attentes, les TR sont fortement infiltrées par des lymphocytes T CD8+ montrant une importante expansion clonale, et que le blocage de PD-1 peut induire la régression des tumeurs chez certains patients. Nous proposons ici d\'étudier la nature des antigènes tumoraux reconnus par les cellules T infiltrantes, en mettant l\'accent sur les antigènes dérivés de la réexpression des rétrovirus endogènes (ERV) due à la perte de SMARCB1. L\'objectif final est de développer de '...; public $post_title = 'Nouvelles immunothérapies anti-tumorales dans les tumeurs rhabdoïdes : ciblage des rétrovirus endogènes'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:31:56'; public $post_modified_gmt = '2025-06-30 16:31:56'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/nouvelles-immunotherapies-anti-tumorales-dans-les-tumeurs-rhabdoides-ciblage-des-retrovirus-endogenes/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36276; public $post_author = '386'; public $post_date = '2025-04-11 16:04:27'; public $post_date_gmt = '2025-04-11 14:04:27'; public $post_content = 'Les tumeurs peuvent contenir des cellules immunitaires immunosuppressives telles que les macrophages associés aux tumeurs (TAMs) qui sont anti-inflammatoires M2 et favorisent les cellules tumorales à résister à l\'apoptose, aux attaques immunitaires et aux thérapies. Éliminer spécifiquement ces TAMs pro-tumoraux est un défi dans les thérapies anticancéreuses, notamment dans le cancer du poumon.\r\nL\'équipe a produit et breveté un anticorps monoclonal, le 6-25 qui cible spécifiquement les TAMs pro-tumoraux M2. Cet anticorps qui est internalisé dans ces cellules, n\'est pas toxique et ne modifie pas leur phénotype. Nous l\'avons donc couplé à une drogue, produisant le 6-25-ADC, qui s’est alors avéré toxique pour les macrophages M2 mais pas pour les macrophages inflammatoires M1 in vitro. L\'objectif du projet est de développer une nouvelle immunothérapie basée sur la déplétion spécifique des TAMs pro-tumoraux, en utilisant le 6-25-ADC, afin de lever la résistance de la tumeur aux traitemen'...; public $post_title = 'Développement d\'un anticorps thérapeutique ciblant les macrophages associés aux tumeurs dans le cancer du poumon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:38:46'; public $post_modified_gmt = '2025-06-30 16:38:46'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/developpement-dun-anticorps-therapeutique-ciblant-les-macrophages-associes-aux-tumeurs-dans-le-cancer-du-poumon/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 38; public $max_num_pages = 13; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '424b4f22346cca5b16c3df2755c9d934'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:6a6495dca83c758cfbc96ab99c5a185d' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34961]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34961], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34961, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34961\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 1; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36726; public $post_author = '1'; public $post_date = '2025-09-23 16:09:29'; public $post_date_gmt = '2025-09-23 14:09:29'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Lyon'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-lyon'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:08:48'; public $post_modified_gmt = '2025-09-24 07:08:48'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36726'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 1; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '2d5dbe2e77bc07a37a469b176dcde0f1'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:1afd4311932ae4b7d18b638802effceb' }, 'titlePost' => TRUE] ) | .../PhpEngine.php:58 |
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