Découvrez l’interview de Julie Helft
Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?
Les macrophages infiltrant les tumeurs sont associés à un mauvais pronostique pour les patients. Cependant les thérapies ciblant les macrophages protumoraux sont peu efficaces. Pour mieux caractériser les macrophages infiltrant les cancers humains, nous avons réalisé du séquençage d’ARN sur cellules uniques provenant d’échantillons cliniques de cancer du sein. Nous avons découvert que les macrophages les plus abondants expriment le récepteur GPNMB et d’autres gènes définissant une signature génique spécifique. L’abondance des transcrits de cette signature corrèle négativement avec la survie des patientes, suggérant un rôle délétère des macrophages GPNMB+.
Nous faisons les hypothèses suivantes : (1) GPNMB est un récepteur inhibiteur; (2) les macrophages GPNMB+ favorisent la croissance tumorale; (3) le ciblage thérapeutique de GPNMB peut avoir un bénéfice clinique dans le cancer du sein.
Nos objectifs sont :
1. De comprendre si GPNMB joue un rôle dans la fonction pro-tumorale des macrophages.
2. D’identifier l’impact de l’expression du récepteur GPNMB dans le microenvironnement tumoral. Nous utiliserons le modèle murin Gpnmb-/- pour tester le rôle de GPNMB sur les populations cellulaires composant le microenvironnement tumoral mammaire.
3. De développer des anticorps ciblant les macrophages GPNMB+ afin de les reprogrammer ou de les dépléter
Ce projet permettra de comprendre le rôle de GPNMB sur la fonction des macrophages intra-tumoraux et son potentiel immunothérapeutique.
Vidéos du projet
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public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../Hooks.php:121 |
| 8 | 1.3145 | 108005408 | Jenssegers\Blade\Blade->render( $view = 'single-project', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3166 | 108063392 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3166 | 108063392 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3166 | 108063448 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3166 | 108064144 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../View.php:139 |
| 13 | 1.3168 | 108064840 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3168 | 108081352 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3168 | 108082112 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3169 | 108102032 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php ) | .../Filesystem.php:107 |
| 17 | 1.3209 | 108247696 | Illuminate\View\View->render( $callback = ??? ) | .../403aef9b1827d569d3508f34a847de4a633c2323.php:31 |
| 18 | 1.3209 | 108247696 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3209 | 108247760 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3209 | 108249096 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }, 'titlePost' => TRUE] ) | .../View.php:139 |
| 21 | 1.3211 | 108249256 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }, 'titlePost' => TRUE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3211 | 108265768 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }, 'titlePost' => TRUE] ) | .../PhpEngine.php:58 |
| 23 | 1.3211 | 108266528 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 24 | 1.3212 | 108277616 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php ) | .../Filesystem.php:107 |
| 25 | 1.3221 | 108358096 | App\Project\Helpers::getInfos( $postID = '34910' ) | .../f0f43a07f44ceff088cb270f157f39cd5180a1f8.php:3 |
| ( ! ) Warning: Undefined variable $axeSDesc in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/app/src/Project/Helpers.php on line 43 | ||||
|---|---|---|---|---|
| Call Stack | ||||
| # | Time | Memory | Function | Location |
| 1 | 0.0001 | 359960 | {main}( ) | .../index.php:0 |
| 2 | 0.0002 | 361312 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ) | .../index.php:17 |
| 3 | 1.1584 | 105065352 | require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ) | .../wp-blog-header.php:19 |
| 4 | 1.1925 | 105558480 | apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ) | .../template-loader.php:114 |
| 5 | 1.1926 | 105558888 | WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ) | .../plugin.php:205 |
| 6 | 1.1926 | 105560424 | Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ) | .../class-wp-hook.php:341 |
| 7 | 1.3143 | 108005328 | Magina\StarterTheme\Template\Helpers::render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../Hooks.php:121 |
| 8 | 1.3145 | 108005408 | Jenssegers\Blade\Blade->render( $view = 'single-project', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3166 | 108063392 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3166 | 108063392 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3166 | 108063448 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3166 | 108064144 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../View.php:139 |
| 13 | 1.3168 | 108064840 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3168 | 108081352 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3168 | 108082112 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3169 | 108102032 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php ) | .../Filesystem.php:107 |
| 17 | 1.3399 | 108731232 | Illuminate\View\View->render( $callback = ??? ) | .../403aef9b1827d569d3508f34a847de4a633c2323.php:31 |
| 18 | 1.3399 | 108731232 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3399 | 108731232 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3399 | 108732568 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }, 'titlePost' => TRUE] ) | .../View.php:139 |
| 21 | 1.3401 | 108732728 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 40; public $max_num_pages = 14; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'c5f9d1b492b1cec15bb827fc3be7a8bd'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:187174f3ac672143d6b4fd613f8ea9f1' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 34910]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 34910], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 34910, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'34910\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = [0 => class WP_Post { public $ID = 36725; public $post_author = '1'; public $post_date = '2025-09-23 16:08:17'; public $post_date_gmt = '2025-09-23 14:08:17'; public $post_content = ''; public $post_title = 'Découvrez l\'interview de Julie Helft'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-linterview-de-julie-helft'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:05:25'; public $post_modified_gmt = '2025-09-24 07:05:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36725'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; public $post_date = '2025-09-23 15:39:53'; public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 2; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '3e4fa2e628e2577b3558be234cdf567d'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:2917771820299d9876b6869719084d2e' }, 'titlePost' => TRUE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3401 | 108749240 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/f0f43a07f44ceff088cb270f157f39cd5180a1f8.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.video-library' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/video-library.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.video-library' => [], 'composing: partials.loop.video-library' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.video-library' => [...], 'composing: partials.loop.video-library' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Le récepteur GPNMB des macrophages : un nouveau point de contrôle de l’immunité anti-tumorale ?'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => [34911 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/lettre-soutien-jh-bms.pdf', 34912 => 'https://fondation-bms.ontest.net/wp-content/uploads/2024/04/helft_julie_bms.pdf'], 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 34910], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '10'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '10', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (34910) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'10\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. Nous analyserons l’effet de cette dérégulation sur la croissance tumorale, la disséminat'...; public $post_title = 'Rôle de la dérégulation de l’inactivation du chromosome X dans l’immunité anti-tumorale : vers une meilleure compréhension des biais de sexe dans le cancer'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-07-01 10:08:45'; public $post_modified_gmt = '2025-07-01 08:08:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-de-la-deregulation-de-linactivation-du-chromosome-x-dans-limmunite-anti-tumorale-vers-une-meilleure-comprehension-des-biais-de-sexe-dans-le-cancer/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36209; public $post_author = '17712'; public $post_date = '2025-04-11 14:11:49'; public $post_date_gmt = '2025-04-11 12:11:49'; public $post_content = 'L’immunothérapie est aujourd’hui reconnue comme le cinquième pilier de la prise en charge du cancer, notamment avec l’avènement des inhibiteurs de points de contrôle immunitaire (ICI), tels que les anticorps anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) et anti-PD-1 (programmed cell death protein 1). Toutefois, la majorité des patients ne répondent pas à ces traitements, soulignant la nécessité d’identifier des marqueurs prédictifs. Si l’expression de PD-1 est bien caractérisée sur les lymphocytes T, son rôle sur les lymphocytes B (LB) reste peu étudié. Nos travaux et la littérature montrent que PD-1 est exprimé à la surface des LB en conditions physiologiques et dans le microenvironnement tumoral. Cependant, l’impact du blocage de PD-1 sur la réponse humorale demeure méconnu. Ce projet vise à évaluer l’effet du blocage de la voie PD-1 sur les LB et leur implication dans la réponse aux ICI, au sein d’une cohorte de patients atteints de cancers et traités par'...; public $post_title = 'Rôle des lymphocytes B dans la réponse aux inhibiteurs de points de contrôle immunitaires'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:12:24'; public $post_modified_gmt = '2025-06-30 16:12:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/role-des-lymphocytes-b-dans-la-reponse-aux-inhibiteurs-de-points-de-controle-immunitaires/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 36116; public $post_author = '17651'; public $post_date = '2025-04-10 18:32:05'; public $post_date_gmt = '2025-04-10 16:32:05'; public $post_content = 'Augmenter le portefeuille des thérapies est essentiel pour répondre aux besoins cliniques et concevoir des schémas de traitements personnalisés pour les patients atteints de cancer. Ainsi, les avancées dans la biologie des cellules Natural Killer (NK) en font une arme de choix. Une compréhension précise de leur diversité fonctionnelle est néanmoins nécessaire pour exploiter pleinement leurs capacités.\r\nNotre hypothèse est que la dégradation des filamines induite par l\'ubiquitine ligase ASB2α dans les sous-populations de cellules NK est un mécanisme qui régule leurs fonctions pro-inflammatoires et antitumorales en contrôlant l\'organisation du cytosquelette d\'actine et/ou la migration, permettant un recrutement optimal des cellules NK au contact des cellules tumorales.\r\nLe but de ce projet est de faire la preuve de principe du potentiel thérapeutique du ciblage de l\'axe ASB2α/filamines dans les cellules NK via la stimulation de leur capacité à infiltrer les tumeurs et éliminer les cellules'...; public $post_title = 'Elargir l\'arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:21:24'; public $post_modified_gmt = '2025-06-30 16:21:24'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/elargir-larsenal-des-immunotherapies-antitumorales-basees-sur-les-cellules-natural-killer-en-ciblant-la-voie-ubiquitine/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = -1; public $before_loop = TRUE; public $in_the_loop = FALSE; public $post = class WP_Post { public $ID = 36329; public $post_author = '278'; public $post_date = '2025-04-11 17:46:09'; public $post_date_gmt = '2025-04-11 15:46:09'; public $post_content = 'Les données épidémiologiques révèlent un biais de sexe dans le cancer, avec une incidence plus élevée et un pronostic moins favorable chez les hommes. Les mécanismes sous-jacents restent peu explorés et insuffisamment pris en compte dans les stratégies thérapeutiques. Nous posons l’hypothèse que des facteurs liés au sexe, notamment le chromosome X, influencent intrinsèquement les cellules immunitaires effectrices comme les T CD8 et NK, favorisant une meilleure réponse anti-tumorale chez les femelles. La présence d’un second chromosome X pourrait conférer un avantage immunitaire via l’expression double de gènes suppresseurs de tumeur EXITS et de nombreux gènes immunitaires localisés sur l’X. Nous étudierons comment la dérégulation de l’inactivation du chromosome X (ICX) dans un modèle murin Ftx-KO, caractérisé par un échappement accru à l’ICX, module l’immunité anti-tumorale. 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public $post_date_gmt = '2025-09-23 13:39:53'; public $post_content = ''; public $post_title = 'Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'decouvrez-la-video-de-la-ceremonie-2024-a-paris-hopital-cochin'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-24 09:02:44'; public $post_modified_gmt = '2025-09-24 07:02:44'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/?post_type=video-library&p=36723'; public $menu_order = 0; public $post_type = 'video-library'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 2; public $current_post = 1; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36723; public $post_author = '1'; 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Découvrez la vidéo de la cérémonie 2024 à Paris, Institut Cochin
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Elargir l’arsenal des immunothérapies antitumorales basées sur les cellules Natural Killer en ciblant la voie ubiquitine