Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas
Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique
Les immunothérapies offrent de nouvelles perspectives dans le traitement du cancer combiné ou non avec d’autres traitements comme la chimiothérapie, la radiothérapie ou les thérapies ciblées. L’évaluation de ces différentes thérapies chez les enfants et les adolescents nécessite la mise en place d’essais cliniques pour lesquels il peut ne pas exister de traitement standard ou le nombre de patients est limité malgré des collaborations. Ce qui pose la question de la faisabilité de ces essais et de l’intérêt de disposer de données historiques. Afin d’accélérer la recherche clinique en immuno-oncologie pédiatrique et donc donner l’accès aux enfants et adolescents à de nouvelles thérapies, le développement de schémas expérimentaux innovants et adaptatifs pour un critère censuré devient nécessaire pour identifier plus rapidement les immunothérapies les plus prometteurs.
Sujets relatifs
| ( ! ) Warning: Undefined variable $axeSDesc in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/app/src/Project/Helpers.php on line 43 | ||||
|---|---|---|---|---|
| Call Stack | ||||
| # | Time | Memory | Function | Location |
| 1 | 0.0002 | 360536 | {main}( ) | .../index.php:0 |
| 2 | 0.0002 | 361888 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ) | .../index.php:17 |
| 3 | 1.1908 | 104991424 | require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ) | .../wp-blog-header.php:19 |
| 4 | 1.2264 | 105486880 | apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ) | .../template-loader.php:114 |
| 5 | 1.2264 | 105487288 | WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ) | .../plugin.php:205 |
| 6 | 1.2264 | 105488824 | Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ) | .../class-wp-hook.php:341 |
| 7 | 1.3285 | 107977024 | Magina\StarterTheme\Template\Helpers::render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }] ) | .../Hooks.php:121 |
| 8 | 1.3287 | 107977104 | Jenssegers\Blade\Blade->render( $view = 'single-project', $data = ['override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }], $mergeData = ??? ) | .../Helpers.php:48 |
| 9 | 1.3305 | 108035088 | Illuminate\View\View->render( $callback = ??? ) | .../Blade.php:47 |
| 10 | 1.3305 | 108035088 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 11 | 1.3305 | 108035144 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 12 | 1.3306 | 108035840 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }] ) | .../View.php:139 |
| 13 | 1.3307 | 108036536 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }] ) | .../CompilerEngine.php:61 |
| 14 | 1.3307 | 108053048 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }] ) | .../PhpEngine.php:58 |
| 15 | 1.3307 | 108053808 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 16 | 1.3309 | 108073728 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/403aef9b1827d569d3508f34a847de4a633c2323.php ) | .../Filesystem.php:107 |
| 17 | 1.3351 | 108195472 | Illuminate\View\View->render( $callback = ??? ) | .../403aef9b1827d569d3508f34a847de4a633c2323.php:40 |
| 18 | 1.3351 | 108195472 | Illuminate\View\View->renderContents( ) | .../View.php:91 |
| 19 | 1.3351 | 108195536 | Illuminate\View\View->getContents( ) | .../View.php:122 |
| 20 | 1.3351 | 108196872 | Illuminate\View\Engines\CompilerEngine->get( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }, 'showAxe' => FALSE] ) | .../View.php:139 |
| 21 | 1.3353 | 108197032 | Illuminate\View\Engines\PhpEngine->evaluatePath( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }, 'showAxe' => FALSE] ) | .../CompilerEngine.php:61 |
| 22 | 1.3353 | 108213544 | Illuminate\Filesystem\Filesystem->getRequire( $path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php', $data = ['__env' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $compiler = class Illuminate\View\Compilers\BladeCompiler { ... }; protected $lastCompiled = [...] }] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $paths = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views']; protected $views = ['single-project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/single-project.blade.php', 'partials.page-header' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/page-header.blade.php', 'partials.breadcrumb' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/breadcrumb.blade.php', 'partials.loop.project' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources/views/partials/loop/project.blade.php']; protected $hints = []; protected $extensions = [0 => 'blade.php', 1 => 'php', 2 => 'css', 3 => 'html'] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = []; protected $bindings = []; protected $methodBindings = []; protected $instances = []; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [], 'composing: single-project' => [], 'creating: partials.page-header' => [], 'composing: partials.page-header' => [], 'creating: partials.breadcrumb' => [], 'composing: partials.breadcrumb' => [], 'creating: partials.loop.project' => [], 'composing: partials.loop.project' => []]; protected $queueResolver = NULL }; protected $container = class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", ... }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [...], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = [...]; protected $customDirectives = [...]; protected $conditions = [...]; protected $precompilers = [...]; protected $path = NULL; protected $compilers = [...]; protected $rawTags = [...]; protected $contentTags = [...]; protected $escapedTags = [...]; protected $echoFormat = 'e(%s)'; protected $footer = [...]; protected $rawBlocks = [...]; protected $classComponentAliases = [...]; protected $classComponentNamespaces = [...]; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = [...]; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }; protected $shared = ['__env' => ..., 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => [...], 'events' => [...], 'config' => [...], 'view' => [...], 'view.finder' => [...], 'blade.compiler' => [...], 'view.engine.resolver' => [...]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { ... }, 'files' => class Illuminate\Filesystem\Filesystem { ... }, 'config' => [...], 'events' => class Illuminate\Events\Dispatcher { ... }, 'view' => ..., 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { ... }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'app' => class Illuminate\Container\Container { protected $resolved = ['view.engine.resolver' => TRUE, 'files' => TRUE, 'config' => TRUE, 'view.finder' => TRUE, 'events' => TRUE, 'view' => TRUE, 'blade.compiler' => TRUE]; protected $bindings = ['files' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'events' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'config' => ['concrete' => class Closure { virtual $closure = "$this->Jenssegers\Blade\{closure}", public $static = [...]; public $this = class Jenssegers\Blade\Blade { ... } }, 'shared' => TRUE], 'view' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.finder' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => FALSE], 'blade.compiler' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... }; public $parameter = [...] }, 'shared' => TRUE], 'view.engine.resolver' => ['concrete' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", public $this = class Illuminate\View\ViewServiceProvider { ... } }, 'shared' => TRUE]]; protected $methodBindings = []; protected $instances = ['view.engine.resolver' => class Illuminate\View\Engines\EngineResolver { protected $resolvers = ['file' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'php' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }, 'blade' => class Closure { virtual $closure = "$this->Illuminate\View\{closure}", ... }]; protected $resolved = ['blade' => class Illuminate\View\Engines\CompilerEngine { ... }] }, 'files' => class Illuminate\Filesystem\Filesystem { }, 'config' => ['view.paths' => [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views'], 'view.compiled' => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'], 'events' => class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { protected $resolved = [...]; protected $bindings = [...]; protected $methodBindings = [...]; protected $instances = [...]; protected $scopedInstances = [...]; protected $aliases = [...]; protected $abstractAliases = [...]; protected $extenders = [...]; protected $tags = [...]; protected $buildStack = [...]; protected $with = [...]; public $contextual = [...]; protected $reboundCallbacks = [...]; protected $globalBeforeResolvingCallbacks = [...]; protected $globalResolvingCallbacks = [...]; protected $globalAfterResolvingCallbacks = [...]; protected $beforeResolvingCallbacks = [...]; protected $resolvingCallbacks = [...]; protected $afterResolvingCallbacks = [...] }; protected $listeners = []; protected $wildcards = []; protected $wildcardsCache = ['creating: single-project' => [...], 'composing: single-project' => [...], 'creating: partials.page-header' => [...], 'composing: partials.page-header' => [...], 'creating: partials.breadcrumb' => [...], 'composing: partials.breadcrumb' => [...], 'creating: partials.loop.project' => [...], 'composing: partials.loop.project' => [...]]; protected $queueResolver = NULL }, 'view' => class Illuminate\View\Factory { protected $engines = class Illuminate\View\Engines\EngineResolver { protected $resolvers = [...]; protected $resolved = [...] }; protected $finder = class Illuminate\View\FileViewFinder { protected $files = class Illuminate\Filesystem\Filesystem { ... }; protected $paths = [...]; protected $views = [...]; protected $hints = [...]; protected $extensions = [...] }; protected $events = class Illuminate\Events\Dispatcher { protected $container = class Illuminate\Container\Container { ... }; protected $listeners = [...]; protected $wildcards = [...]; protected $wildcardsCache = [...]; protected $queueResolver = NULL }; protected $container = ...; protected $shared = ['__env' => ..., 'app' => ...]; protected $extensions = ['blade.php' => 'blade', 'php' => 'php', 'css' => 'file', 'html' => 'file']; protected $composers = []; protected $renderCount = 2; protected $renderedOnce = []; protected $componentStack = []; protected $componentData = []; protected $currentComponentData = []; protected $slots = []; protected $slotStack = []; protected $sections = []; protected $sectionStack = [0 => 'content']; protected $loopsStack = []; protected $pushes = []; protected $prepends = []; protected $pushStack = []; protected $translationReplacements = [] }, 'blade.compiler' => class Illuminate\View\Compilers\BladeCompiler { protected $files = class Illuminate\Filesystem\Filesystem { }; protected $cachePath = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/uploads/cache'; protected $extensions = []; protected $customDirectives = ['asset' => [...], 'shortcode' => [...], 'debug' => [...], 'svg' => [...]]; protected $conditions = []; protected $precompilers = []; protected $path = NULL; protected $compilers = [0 => 'Extensions', 1 => 'Statements', 2 => 'Echos']; protected $rawTags = [0 => '{!!', 1 => '!!}']; protected $contentTags = [0 => '{{', 1 => '}}']; protected $escapedTags = [0 => '{{{', 1 => '}}}']; protected $echoFormat = 'e(%s)'; protected $footer = []; protected $rawBlocks = []; protected $classComponentAliases = ['dynamic-component' => 'Illuminate\\View\\DynamicComponent']; protected $classComponentNamespaces = []; protected $compilesComponentTags = TRUE; protected $firstCaseInSwitch = TRUE; protected $echoHandlers = []; private $encodingOptions = 15; protected $lastSection = NULL; protected $forElseCounter = 0 }]; protected $scopedInstances = []; protected $aliases = []; protected $abstractAliases = []; protected $extenders = []; protected $tags = []; protected $buildStack = []; protected $with = []; public $contextual = []; protected $reboundCallbacks = []; protected $globalBeforeResolvingCallbacks = []; protected $globalResolvingCallbacks = []; protected $globalAfterResolvingCallbacks = []; protected $beforeResolvingCallbacks = []; protected $resolvingCallbacks = []; protected $afterResolvingCallbacks = [] }, 'override' => 'app', 'display_sidebar' => FALSE, 'breadLinks' => ['/projets' => 'Tous les appels à projets', '#' => 'Développement de schémas expérimentaux adaptatifs innovants pour l’évaluation d’immunothérapies en oncologie pour un critère censuré avec un groupe contrôle historique'], 'bgHeader' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgHeaderMobile' => '/wp-content/themes/fondation-bms/dist/images/single_project.png?id=99b291f1ee8787533ce0', 'bgLink' => '', 'isEvaluator' => FALSE, 'isAdmin' => FALSE, 'attachments' => '', 'relatedPjs' => class WP_Query { public $query = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492]]; public $query_vars = ['post_type' => 'project', 'posts_per_page' => 3, 'meta_query' => [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes']], 'post__not_in' => [0 => 2492], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => FALSE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => '_pj_axe_primary', 'value' => '12'], 1 => ['key' => '_pj_winner', 'value' => 'yes'], 'relation' => 'AND']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta', 1 => 'mt1']; protected $clauses = ['wp_postmeta' => ['key' => '_pj_axe_primary', 'value' => '12', 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR'], 'mt1' => ['key' => '_pj_winner', 'value' => 'yes', 'compare' => '=', 'compare_key' => '=', 'alias' => 'mt1', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id ) INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )\n\t\t\t\t\t WHERE 1=1 AND wp_posts.ID NOT IN (2492) AND ( \n ( wp_postmeta.meta_key = \'_pj_axe_primary\' AND wp_postmeta.meta_value = \'12\' ) \n AND \n ( mt1.meta_key = \'_pj_winner\' AND mt1.meta_value = \'yes\' )\n) AND ((wp_posts.post_type = \'project\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t LIMIT 0, 3'; public $posts = [0 => class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 1 => class WP_Post { public $ID = 36023; public $post_author = '17551'; public $post_date = '2025-04-10 14:08:06'; public $post_date_gmt = '2025-04-10 12:08:06'; public $post_content = 'Les déficits immunitaires héréditaires (DIH) sont dus à des défauts génétiques constitutionnels affectant le système immunitaire. Ils sont diagnostiqués dans l\'enfance et prédisposent aux lymphomes. Le paysage génétique des lymphomes du DIH est mal connu. Les pronostics sont mauvais et leur traitement n’est pas codifié. De plus, le lymphome peut constituer la première manifestation d’un DIH non diagnostiqué jusqu’alors.\r\nCe projet vise à établir une plateforme d’étude des lymphomes liés aux DIH, issus du registre national des DIH (CEREDIH, n > 8000 patients), en utilisant une approche pan-omique intégrative. Une analyse comparative avec les lymphomes de l’immunocompétent permettra d’identifier des biomarqueurs de DIH sous-jacent chez des enfants développant un lymphome.\r\nCette étude devrait révéler le paysage moléculaire des lymphomes associés aux DIH et identifier de potentielles cibles thérapeutiques. Nous développerons des biomarqueurs prédictifs d’un DIH non '...; public $post_title = 'Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:04:45'; public $post_modified_gmt = '2025-06-30 16:04:45'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/des-lymphomes-aux-deficits-immunitaires-et-vice-versa-flip/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }, 2 => class WP_Post { public $ID = 35068; public $post_author = '17496'; public $post_date = '2024-04-11 10:22:45'; public $post_date_gmt = '2024-04-11 08:22:45'; public $post_content = 'Les leucémies aigües myéloblastiques (LAM) de l’enfant, dont la survie est de 70%, sont classées en LAM de risque standard, intermédiaire ou élevé en fonction des anomalies cytogénétiques des cellules blastiques. Cette stratification va guider la prise en charge qui repose sur la chimiothérapie intensive et l’allogreffe de cellules souches hématopoiétiques (CSH) qui sera réalisée d’emblée chez les patients de « haut » risque et seulement en cas de rechute chez les patients de risque standard ou intermédiaire. Même si l’allogreffe de CSH permet de guérir la majorité des patients de risque standard ou intermédiaire, elle n’est pas dénuée de risques. De nouvelles stratégies doivent donc être explorées pour diminuer le risque de rechute. L’immunothérapie pourrait être une piste intéressante avec l’idée de vaccins à ARNm ciblant des néoantigènes (néoAg) tumoraux, comme cela commence à se faire dans les tumeurs solides. Les objectifs de notre étude sont : 1/ D’id'...; public $post_title = 'Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-09-23 16:17:25'; public $post_modified_gmt = '2025-09-23 14:17:25'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/cibler-les-lymphocytes-t-dans-les-leucemies-aigues-myeloblastiques-pediatriques/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }]; public $post_count = 3; public $current_post = 0; public $before_loop = FALSE; public $in_the_loop = TRUE; public $post = class WP_Post { public $ID = 36194; public $post_author = '70'; public $post_date = '2025-04-11 13:12:34'; public $post_date_gmt = '2025-04-11 11:12:34'; public $post_content = 'Le gliome diffus de la ligne médiane, muté H3K27M, est une entité regroupant la plupart les DIPG ainsi que d\'autres tumeurs, principalement localisées dans le thalamus. Outre leur aspect diffus, ces tumeurs sont caractérisées par une mutation entraînant la substitution H3K27 dans la queue N-terminale de l\'histone H3. Le pronostic des DMG est très sombre, la plupart des patients décédant dans l\'année suivant le diagnostic, et aucune amélioration de la survie n\'a été réalisée depuis plus de 30 ans. Les approches immuno-thérapeutiques offrent un espoir, mais des modèles animaux sont nécessaires pour comprendre et évaluer leur efficacité.\r\nAvec notre projet SYNGENIC-DMG nous souhaitons développer un modèle murin DMG syngénique immunocompétent pertinent en induisant des tumeurs reproduisant les caractéristiques des DMG. Ceci nous permettra de décrire l\'environnement immunitaire tumoral au fil du temps et ainsi décrypter comment la tumeur altère le compartiment immunitaire. Ces données'...; public $post_title = 'Syngenic-DMG: a study platform to decipher longitudinal tumor and immune microenvironment crosstalks in pediatric diffuse midline gliomas'; public $post_excerpt = ''; public $post_status = 'publish'; public $comment_status = 'closed'; public $ping_status = 'closed'; public $post_password = ''; public $post_name = 'syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas'; public $to_ping = ''; public $pinged = ''; public $post_modified = '2025-06-30 18:07:19'; public $post_modified_gmt = '2025-06-30 16:07:19'; public $post_content_filtered = ''; public $post_parent = 0; public $guid = 'https://fondation-bms.ontest.net/projets/syngenic-dmg-a-study-platform-to-decipher-longitudinal-tumor-and-immune-microenvironment-crosstalks-in-pediatric-diffuse-midline-gliomas/'; public $menu_order = 0; public $post_type = 'project'; public $post_mime_type = ''; public $comment_count = '0'; public $filter = 'raw' }; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 16; public $max_num_pages = 6; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = '7be0868e677d2d2687b8647419b181cc'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:c67dca3aa1825a98de0ffdce4a8bbefe' }, 'updates' => '', 'months' => [0 => '', 1 => 'Janvier', 2 => 'Février', 3 => 'Mars', 4 => 'Avril', 5 => 'Mai', 6 => 'Juin', 7 => 'Juillet', 8 => 'Aout', 9 => 'Septembre', 10 => 'Octobre', 11 => 'Novembre', 12 => 'Décembre'], 'videos' => class WP_Query { public $query = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]]]; public $query_vars = ['post_type' => 'video-library', 'posts_per_page' => -1, 'meta_query' => [0 => ['key' => 'related_project', 'value' => 2492]], 'error' => '', 'm' => '', 'p' => 0, 'post_parent' => '', 'subpost' => '', 'subpost_id' => '', 'attachment' => '', 'attachment_id' => 0, 'name' => '', 'pagename' => '', 'page_id' => 0, 'second' => '', 'minute' => '', 'hour' => '', 'day' => 0, 'monthnum' => 0, 'year' => 0, 'w' => 0, 'category_name' => '', 'tag' => '', 'cat' => '', 'tag_id' => '', 'author' => '', 'author_name' => '', 'feed' => '', 'tb' => '', 'paged' => 0, 'meta_key' => '', 'meta_value' => '', 'preview' => '', 's' => '', 'sentence' => '', 'title' => '', 'fields' => 'all', 'menu_order' => '', 'embed' => '', 'category__in' => [], 'category__not_in' => [], 'category__and' => [], 'post__in' => [], 'post__not_in' => [], 'post_name__in' => [], 'tag__in' => [], 'tag__not_in' => [], 'tag__and' => [], 'tag_slug__in' => [], 'tag_slug__and' => [], 'post_parent__in' => [], 'post_parent__not_in' => [], 'author__in' => [], 'author__not_in' => [], 'search_columns' => [], 'ignore_sticky_posts' => FALSE, 'suppress_filters' => FALSE, 'cache_results' => TRUE, 'update_post_term_cache' => TRUE, 'update_menu_item_cache' => FALSE, 'lazy_load_term_meta' => TRUE, 'update_post_meta_cache' => TRUE, 'nopaging' => TRUE, 'comments_per_page' => '50', 'no_found_rows' => FALSE, 'order' => 'DESC']; public $tax_query = class WP_Tax_Query { public $queries = []; public $relation = 'AND'; protected $table_aliases = []; public $queried_terms = []; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID' }; public $meta_query = class WP_Meta_Query { public $queries = [0 => ['key' => 'related_project', 'value' => 2492], 'relation' => 'OR']; public $relation = 'AND'; public $meta_table = 'wp_postmeta'; public $meta_id_column = 'post_id'; public $primary_table = 'wp_posts'; public $primary_id_column = 'ID'; protected $table_aliases = [0 => 'wp_postmeta']; protected $clauses = ['wp_postmeta' => ['key' => 'related_project', 'value' => 2492, 'compare' => '=', 'compare_key' => '=', 'alias' => 'wp_postmeta', 'cast' => 'CHAR']]; protected $has_or_relation = FALSE }; public $date_query = FALSE; public $queried_object = *uninitialized*; public $queried_object_id = *uninitialized*; public $request = 'SELECT wp_posts.*\n\t\t\t\t\t FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )\n\t\t\t\t\t WHERE 1=1 AND ( \n ( wp_postmeta.meta_key = \'related_project\' AND wp_postmeta.meta_value = \'2492\' )\n) AND ((wp_posts.post_type = \'video-library\' AND (wp_posts.post_status = \'publish\')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.post_date DESC\n\t\t\t\t\t '; public $posts = []; public $post_count = 0; public $current_post = -1; public $before_loop = FALSE; public $in_the_loop = FALSE; public $post = *uninitialized*; public $comments = *uninitialized*; public $comment_count = 0; public $current_comment = -1; public $comment = *uninitialized*; public $found_posts = 0; public $max_num_pages = 0; public $max_num_comment_pages = 0; public $is_single = FALSE; public $is_preview = FALSE; public $is_page = FALSE; public $is_archive = TRUE; public $is_date = FALSE; public $is_year = FALSE; public $is_month = FALSE; public $is_day = FALSE; public $is_time = FALSE; public $is_author = FALSE; public $is_category = FALSE; public $is_tag = FALSE; public $is_tax = FALSE; public $is_search = FALSE; public $is_feed = FALSE; public $is_comment_feed = FALSE; public $is_trackback = FALSE; public $is_home = FALSE; public $is_privacy_policy = FALSE; public $is_404 = FALSE; public $is_embed = FALSE; public $is_paged = FALSE; public $is_admin = FALSE; public $is_attachment = FALSE; public $is_singular = FALSE; public $is_robots = FALSE; public $is_favicon = FALSE; public $is_posts_page = FALSE; public $is_post_type_archive = TRUE; private $query_vars_hash = 'f1de7bf18abe0aab7bf998855bc98867'; private $query_vars_changed = FALSE; public $thumbnails_cached = FALSE; protected $allow_query_attachment_by_filename = FALSE; private $stopwords = NULL; private $compat_fields = [0 => 'query_vars_hash', 1 => 'query_vars_changed']; private $compat_methods = [0 => 'init_query_flags', 1 => 'parse_tax_query']; private $query_cache_key = 'wp_query:67dd69dcfbad2643f183300fc26bd6e8' }, 'showAxe' => FALSE] ) | .../PhpEngine.php:58 |
| 23 | 1.3353 | 108214304 | Illuminate\Filesystem\Filesystem::Illuminate\Filesystem\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/illuminate/filesystem/Filesystem.php:104-108}( ) | .../Filesystem.php:108 |
| 24 | 1.3354 | 108225600 | require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/resources/uploads/cache/58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php ) | .../Filesystem.php:107 |
| 25 | 1.3362 | 108306080 | App\Project\Helpers::getInfos( $postID = 36194 ) | .../58e71303448da4a5f8cfa0b20dbd5468bf1ead2a.php:1 |
Des Lymphomes aux Déficits Immunitaires, et vice-versa (FLIP)
Cibler les lymphocytes T dans les leucémies aigües myéloblastiques pédiatriques