( ! ) Notice: La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.) in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0002360536{main}( ).../index.php:0
20.0003361888require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0561104990312require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0849105467152apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0849105467560WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0849105469096Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0849105469576Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0850105477016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0850105493784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0850105494160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0850105494160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.0851105496616wp_enqueue_scripts( '' ).../class-wp-hook.php:341
131.0851105496616do_action( $hook_name = 'wp_enqueue_scripts' ).../script-loader.php:2311
141.0851105496992WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
151.0851105496992WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
161.1179105877624App\Setup\Hooks->enqueueAssets( '' ).../class-wp-hook.php:341
171.1180105877728wp_localize_script( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../Hooks.php:138
181.1180105877728WP_Scripts->localize( $handle = 'scripts/pages/app.compiled.js', $object_name = 'adminAjax', $l10n = 'https://fondation-bms.ontest.net/wp-admin/admin-ajax.php' ).../functions.wp-scripts.php:233
191.1181105878048_doing_it_wrong( $function_name = 'WP_Scripts::localize', $message = 'Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>.', $version = '5.7.0' ).../class-wp-scripts.php:616
201.1182105879392wp_trigger_error( $function_name = '', $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = ??? ).../functions.php:6071
211.1184105879864trigger_error( $message = 'La fonction WP_Scripts::localize a été appelée de façon <strong>incorrecte</strong>. Le paramètre <code>$l10n</code> doit être un tableau. Pour transmettre des données arbitraires aux scripts, utilisez plutôt la fonction <code>wp_add_inline_script()</code>. Veuillez lire <a href="https://developer.wordpress.org/advanced-administration/debug/debug-wordpress/">Débogage dans WordPress</a> (en) pour plus d’informations. (Ce message a été ajouté à la version 5.7.0.)', $error_level = 1024 ).../functions.php:6131
Régulation de l’échappement tumoral à l'immuno-surveillance par les lipide-kinases SphK: intérêt de l’inhibition combinée de SphKs et de points de contrôle immunitaires en oncoimmunologie - Fondation BMS
( ! ) Notice: file_get_contents(): Read of 8192 bytes failed with errno=21 Is a directory in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 4681
Call Stack
#TimeMemoryFunctionLocation
10.0002360536{main}( ).../index.php:0
20.0003361888require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0561104990312require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0849105467152apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0849105467560WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0849105469096Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0849105469576Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0850105477016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0850105493784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0850105494160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0850105494160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1627107334408wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.1627107334408WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.1627107334408wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.1628107334464WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.1830107887320WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.1831107887960WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.1831107887960wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.1832107888448file_get_contents( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources' ).../functions.php:4681

( ! ) Notice: wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error in /var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/functions.php on line 6131
Call Stack
#TimeMemoryFunctionLocation
10.0002360536{main}( ).../index.php:0
20.0003361888require( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-blog-header.php ).../index.php:17
31.0561104990312require_once( '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-includes/template-loader.php ).../wp-blog-header.php:19
41.0849105467152apply_filters( $hook_name = 'template_include', $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../template-loader.php:114
51.0849105467560WP_Hook->apply_filters( $value = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php', $args = [0 => '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php'] ).../plugin.php:205
61.0849105469096Magina\StarterTheme\Template\Hooks->render( $template = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources/views/single-project.blade.php' ).../class-wp-hook.php:341
71.0849105469576Illuminate\Support\Collection->each( $callback = class Closure { virtual $closure = "$this->Magina\StarterTheme\Template\{closure}", public $this = class Magina\StarterTheme\Template\Hooks { }; public $parameter = ['$tag' => '<required>'] } ).../Hooks.php:115
81.0850105477016Magina\StarterTheme\Template\Hooks->Magina\StarterTheme\Template\{closure:/var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/vendor/magina/starter-theme-templating-module/src/Hooks.php:107-115}( $tag = 'wp_head', 1 ).../EnumeratesValues.php:245
91.0850105493784do_action( $hook_name = 'wp_head' ).../Hooks.php:109
101.0850105494160WP_Hook->do_action( $args = [0 => ''] ).../plugin.php:522
111.0850105494160WP_Hook->apply_filters( $value = '', $args = [0 => ''] ).../class-wp-hook.php:365
121.1627107334408wp_print_font_faces( $fonts = '' ).../class-wp-hook.php:341
131.1627107334408WP_Font_Face_Resolver::get_fonts_from_theme_json( ).../fonts.php:46
141.1627107334408wp_get_global_settings( $path = ???, $context = ??? ).../class-wp-font-face-resolver.php:29
151.1628107334464WP_Theme_JSON_Resolver::get_merged_data( $origin = 'custom' ).../global-styles-and-settings.php:80
161.1830107887320WP_Theme_JSON_Resolver::get_theme_data( $deprecated = ???, $options = ??? ).../class-wp-theme-json-resolver.php:668
171.1831107887960WP_Theme_JSON_Resolver::read_json_file( $file_path = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources' ).../class-wp-theme-json-resolver.php:255
181.1831107887960wp_json_file_decode( $filename = '/var/www/vhosts/fondation-bms.ontest.net/httpdocs/wp/wp-content/themes/fondation-bms/resources', $options = ['associative' => TRUE] ).../class-wp-theme-json-resolver.php:110
191.1845107913704wp_trigger_error( $function_name = 'wp_json_file_decode', $message = 'Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = ??? ).../functions.php:4690
201.1846107914024trigger_error( $message = 'wp_json_file_decode(): Erreur lors du décodage du fichier JSON à l’emplacement /var/www/vhosts/fondation-bms.ontest.net/httpdocs/src/themes/fondation-bms/resources : Syntax error', $error_level = 1024 ).../functions.php:6131

Régulation de l’échappement tumoral à l’immuno-surveillance par les lipide-kinases SphK: intérêt de l’inhibition combinée de SphKs et de points de contrôle immunitaires en oncoimmunologie

L’immunothérapie ciblant les points de contrôle immunitaires (ICB) constitue indiscutablement une arme thérapeutique de choix contre des cancers métastatiques agressifs mais n’est efficace que chez un quart des patients en moyenne, avec de fortes disparités selon le type de cancer. L’enjeu est désormais de trouver des combinaisons thérapeutiques plus efficaces. Nos résultats préliminaires indiquent que le ciblage des lipide-kinases SphK est associé à une réduction de l’accumulation et de la fonction de populations immunosuppressives dans le microenvironnement tumoral. L’inhibition de SphKs montre un effet synergique avec les ICB sur la réponse anti-tumorale chez la souris. Ce projet vise à identifier (i) les mécanismes moléculaires et cellulaires par lesquels les SphKs régulent l’échappement au système immunitaire et (ii) si les SphKs constituent des biomarqueurs prédictifs de la réponse de patients traités par ICB.

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